منابع مشابه
Further Characterization of Factor VIII - Deficient Mice Created by Gene
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متن کاملMice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels
Von Willebrand factor (VWF) is the carrier protein of the anti-haemophilic Factor VIII (FVIII) in plasma. It has been reported that the infusion of FVIII concentrate in haemophilia A patients results in lowered VWF plasma levels. However, the impact of F8-deficiency on VWF plasma levels in F8-/y mice is unresolved. In order to avoid confounding variables, we back-crossed F8-deficient mice onto ...
متن کاملFurther characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies.
Previously we created two strains of factor VIII-deficient mice by insertion of a neo gene into (1) the 3' end of exon 16 and (2) exon 17 of the factor VIII gene. Affected mice of both strains have no plasma factor VIII activity, yet are healthy with no spontaneous bleeding. Factor VIII-deficient females bred with affected males survive pregnancy and delivery. We used reverse transcriptase-poly...
متن کامل"thrombocytopenic Serum": an Artificial Factor Viii-deficient Reagent.
Thrombocytopenic serum is a simple reagent derived from platelet-poor plasma. The high levels of factor V and ;zero' levels of factor VIII in this reagent make it a reliable alternative to haemophilia A plasma in the qualitative and quantitative assessment of factor VIII in the thromboplastin generation test.
متن کاملFACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1997
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.8.417